As said already, this specific chip cannot support socketed memory. And personally, I don't really think Framework needs to enter the regular desktop hardware market which is already well-served by a thriving ecosystem of multiple hardware vendors collaborating around a well-defined standard (ATX).
The "Framework Desktop", with this specific choice of hardware, seems to be more of a competitor to the likes of the Mac Studio than to anything that could already be custom-built today anyways. While I think its naming choice might be a bit poor due to it being conflated with that desktop market, I think it's a natural fit as something fairly laptop-adjacent and thus close to Framework's existing efforts and strengths.
I'm on a bit of a Dragon Quest kick right now so I wouldn't mind, but VII seems like the absolute strangest choice to remake. It wasn't that long ago that the 3DS remake came out, which IMO was a fine remake all the way through (I'm ok with the shortened intro, having played through the first chunk of the PS1 original). I expect perhaps that version wouldn't hold up to modern scrutiny even on Switch/Steam Deck-style handhelds, but it feels like the effort would be better spent on getting a game like VIII which did feel compromised a slight bit in its 3DS iteration, or IX which has never seen a rerelease since the DS, a more proper remake?
VII is notably the only current missing game from the pre-IX offerings on mobile. I don't personally care for playing these games on mobile devices but I don't know how much of an impact that market has.