sndrtj

joined 2 years ago
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[–] sndrtj@feddit.nl 3 points 2 years ago

Statistics would indicate that that is a plausible scenario.

In addition, a uniparental disomy can occur as well. Here, the X chromosome was duplicated in the egg cell. So the exact same X chromosome is inherited twice.This is an error in meiosis. This could occur in XXX (with the third X from the father's side), XXY, or even XX. That latter one would be rare, for a uniparental disomy on X without a third sex chromosome would mean both egg and sperm cell had an error during meiosis.

You could also see a single X (Turner Syndrome) as a 100% dominant X-chromosome. But that may be semantics.

[–] sndrtj@feddit.nl 6 points 2 years ago (2 children)

X-inactivation is a little bit more complicated than that. While the process of X-inactivation initiation is random, once a cell has settled on one chromosome, all its daughter cells will silence the same chromosome. The initial process happens in the early embryo, so large patches of the body have the same X chromosome silenced.

This pattern is visible in some animals. E.g. a tortoise cat's pattern arises due to the hair color gene existing on the X chromosome. Consequently, male tortoise cats are rare (XXY, XXXY etc only)

[–] sndrtj@feddit.nl 2 points 2 years ago

Also certain fields (cough cough medicine) needs to consider more than just the p value. With any large sample size you're almost guaranteed to find a "significant" result in some test, but the effect sizes are often so tiny to be basically meaningless.

[–] sndrtj@feddit.nl 1 points 2 years ago

That's the exact problem OP is referring to.

[–] sndrtj@feddit.nl 4 points 2 years ago

I'm finding it useful for detecting / correcting really simple mistakes, syntax errors and stuff like that.

But I'm finding it mostly useless for anything more complicated.

[–] sndrtj@feddit.nl 1 points 2 years ago (1 children)

Ik heb OpenFiber. Alleen beschikbaar voor nieuwbouw in de regio Haaglanden. 19/maand voor 1000/1000 en TV.

[–] sndrtj@feddit.nl 6 points 2 years ago

And the dystopia continues....

[–] sndrtj@feddit.nl 1 points 2 years ago

Drie jaar te laat.

Wij hadden een complexe situatie tijdens corona (had niks met corona te maken). Belastingtelefoonmedewerker 1 zegt maak een afspraak, belastingtelefoonmedewerker 2 laat weten dat dat niet mogelijk is tijdens een lockdown. Resultaat: waarschijnlijk 1000 euro teveel belasting betaald.

[–] sndrtj@feddit.nl 37 points 2 years ago (2 children)

Flat design. I don't know what a button is anymore. Often I randomly click through an UI to see if it's a clickable element or just a text box. Please give me back skeuomorphic design.

[–] sndrtj@feddit.nl 11 points 2 years ago

This is very much the default in the Netherlands. Yes theft happens, but your license plate will be clearly visibly on CCTV meaning you will get a visit by police soon after.

[–] sndrtj@feddit.nl 1 points 2 years ago

Would this plan remove all ads? Only then I'd consider it.

[–] sndrtj@feddit.nl 2 points 2 years ago

It's soo simple, but soooo good.

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