Yes. You probably will miss out on branching paths if any exist, but you will miss out on those in a regular playthrough anyway.
You also probably should've asked this question instead of the one in the title of the thread—they're two fundamentally different questions.
I know narrative-driven games are dominant nowadays, but not every game is narrative-driven.
I upvoted for the Jon Benjamin mention. Jon Benjamin Has a Van is so fucking funny.
And I love Bob's Burgers, but Home Movies was magic and I consider it his peak VA work.