justdoit

joined 2 years ago
[–] justdoit@lemm.ee 6 points 2 years ago (3 children)

We should really have another name other than “think tank” because I’m not convinced there’s a lot of thinking going on here.

Suggestions?

[–] justdoit@lemm.ee 104 points 2 years ago (1 children)

The admin note there was pretty hilarious.

“We’re being censored because big instances defederated from us!” Bitch you can still scream your shit into whatever instances that still want to share the cesspool with you.

This is the real world equivalent of shouting into a megaphone outside a bar and claiming censorship when they close their doors to shut out the noise.

[–] justdoit@lemm.ee 12 points 2 years ago

Poor missionaries. Teenagers are far too young to be involved in something like this. Even the victims are perpetrators in Mormonism

[–] justdoit@lemm.ee 0 points 2 years ago

Could you link to said reputable polls? Just for the sake of being thorough

[–] justdoit@lemm.ee 6 points 2 years ago (5 children)

Good. Here’s hoping for a swift trial.

[–] justdoit@lemm.ee 27 points 2 years ago

Now this is unpopular.

May god have mercy on your soul. LotR memes was one of the first communities to migrate over.

[–] justdoit@lemm.ee 10 points 2 years ago

Look, I’m all for reforestation efforts, and if Rs are willing to start a large environmental project like that, great. But, it’s really not a solution for climate change on a global scale. At best it’s a repair effort for the damage already done.

Even if they get the scale right, and somehow manage to plant and cultivate a trillion trees successfully, trees are more of a short-term carbon sink when you’re talking about a geological time scale. They die, they burn, they get chopped down. When that happens, the carbon is liberated again. Sure, you can plant more trees, but all you’re doing is changing the equilibrium point for atmospheric CO2. With each gallon of gas burned, more CO2 enters the cycle that would have otherwise remained in the ground long term. Trying to solve climate change by reforestation is like trying to fill a leaky bucket with water. No matter how much you pour in there, at some point you’ll have to stop the leak.

The answer to climate change is the same, yesterday, today, and forever: long term carbon sinks (fossil fuels and chemical weathering) cannot liberate CO2 at the rate we’re currently running. Reduction is the only real answer.

[–] justdoit@lemm.ee 12 points 2 years ago

Yes. Though I’d point out that HRT covers a much broader range of pathologies than what the current media landscape covers.

As far as I understand, in the original etymology, “replacement” in HRT referred to the fact that the hormone source is coming externally to buoy up a diminished supply in the body. It’s not (necessarily) referring to “displacement” of a hormone that’s already there. More like this usage: when you run out of milk, you go to the store to replace it.

Technically menopausal hormone therapy is HRT, for example. Testosterone replacement in males with low circulating levels is another. Nowadays the usage is definitely shifting, though, and clearly it has a different colloquial meaning.

[–] justdoit@lemm.ee 3 points 2 years ago

Ohhh, I see my confusion now. My original comment was about Swyer syndrome, not CAIS. CAIS and Swyer Syndrome are very similar in concept but have a lot of important differences, especially in gonadal development. Usually in CAIS the testes will develop which can produce sex hormones, while Swyer syndrome leads to streak gonads which are generally functionless. Seems like there’s quite a debate about the timing of gonadectomy in CAIS indeed.

[–] justdoit@lemm.ee 3 points 2 years ago (2 children)

So disclaimer here, I’m only savvy on the molecular bio and can’t speak as much to the actual healthcare side of things, but the actual diagnosis is a little more complex than what I’ve written here. Sometimes streak gonads (gonadal tissue which failed to become fully functional ovaries or testes) will still contain some testis or ovarian tissue which will produce hormones. Just depends on the severity of the gonadal dysgenesis.

But as you’ve written it here is seems NPR is implying the surgery itself causes bone density issues? Those issues arise due to an absence of sex hormones, which would still be a problem in complete gonadal dysgenesis. This is why treatment is usually paired with hormone therapy as well as surgery.

I can’t speak to the relative risks of either, though. As with any surgery and treatment, it’s a medical decision with a lot of factors.

[–] justdoit@lemm.ee 3 points 2 years ago

Very true. Both syndromes fit the bill here.

[–] justdoit@lemm.ee 23 points 2 years ago

Not in humans, no! While in some animals sex determination is purely about X dosage (Drosophila), in humans the Y chromosome is actually sex-determining. In females the second X chromosome actually gets inactivated as a means of gene dosage compensation.

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