bandario

Not a bad idea with the kayaks. I just bought a couple of old style geoff barker kayaks/ canoes from an old bloke who does that as a hobby. The old style fibreglass kayaks really lend themselves to easy and quality repair jobs. I felt like we both got a win out of the sale.

They're pretty fun on the water compared to my old plastic behemoths. So easy to load and unload and takes almost zero energy input to paddle. Bloody easy to tip them over though!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976712/

It's significant. Biggest effect is on efficacy of drug metabolism. There are many such studies.

One size does not fit all here owing to differences in expression of metabolising enzymes and drug transport mechanisms.

No, the Japanese are not aliens but they may require far less of a given drug than a westerner, or far more. This affects the likelihood to experience side effects for any given compound, and their severity.

It's fairly ironic to make this change for Japan whilst elsewhere in the world with more racially mixed populations there has been a push in the opposite direction: a recognition that you cannot assume the results of a trial carried out on white male subjects will apply to those of African descent for example.

It's not just drug treatments either. There are many aspects of medical care which have suffered from a lack of specificity and systemic bias.

If you're considering a side hustle, the best one is preparing yourself to apply for a job that pays a living wage.

We shouldn't have to work in our downtime to live a good life.

I know enough to believe this isn't a great idea.

Genetic variation in target populations can result in different outcomes for a variety of treatments and is worth testing specifically.

I'm not in the USA. I think after shipping was included the Unicomp came out at almost $400AUD - it's just not feasible. Similar for ebay sales from USA.

I've consoled myself with an 8bitDo retro keyboard. It's pretty slick! Obviously not buckling spring, but it is wireless and has a volume knob. It really does remind me of a vic20 keyboard in feel.

Score.

I'm so desperate to get hold of one.

The irony is, I threw literally hundreds of them into skip bins in the late 90's doing IT work and didn't think anything of it.

Live and learn. The hoarders got it right.

Where'd you get it?

I have also walked away from the franchise. I played the MW3 beta and it was an identical game to the one prior.

They didn't fix any of the things that ruined it.

The trouble is, there's really nothing else comparable that has a playerbase.

My friends and I tried BF2042 for a while. It's ok but still a pretty weak BF title IMO and even when you're winning, not all that rewarding.

There's plenty of milsim titles with players, plenty of battle Royale titles with players, and CSGO still massive.

What is missing is arcade style shooters like COD that are not COD, or movement based shooters. Whilst there's plenty on offer, nobody is playing them.

I know there's some cool stuff in the pipeline. 'The Finals' play test was really cool but kept getting booted for "cheating". A few others coming but right now there's just nothing.

8BitDo retro keyboard. Honestly I'm blown away by the quality and feel of this thing. They did an incredible job.

My thoughts exactly. It just seems like SO MUCH WORK. It's difficult enough balancing a career, children and keeping one relationship healthy.

Pretty soon it will ONLY be the pirates that have access to a lot of this content. You should think of it is a global community service.

I strongly advocate for the revival of thou! Thou shalt yield.