RobotToaster

cross-posted from: https://derp.foo/post/291129

cross-posted from: https://lemmy.world/post/6282483

A vaccine against tuberculosis, the world’s deadliest infectious disease, has never been closer to reality, with the potential to save millions of lives. But its development slowed after its corporate owner focused on more profitable vaccines.

Ever since he was a medical student, Dr. Neil Martinson has confronted the horrors of tuberculosis, the world’s oldest and deadliest pandemic. For more than 30 years, patients have streamed into the South African clinics where he has worked — migrant workers, malnourished children and pregnant women with HIV — coughing up blood. Some were so emaciated, he could see their ribs. They’d breathed in the contagious bacteria from a cough on a crowded bus or in the homes of loved ones who didn’t know they had TB. Once infected, their best option was to spend months swallowing pills that often carried terrible side effects. Many died.

So, when Martinson joined a call in April 2018, he was anxious for the verdict about a tuberculosis vaccine he’d helped test on hundreds of people.

The results blew him away: The shot prevented over half of those infected from getting sick; it was the biggest TB vaccine breakthrough in a century. He hung up, excited, and waited for the next step, a trial that would determine whether the shot was safe and effective enough to sell.

Weeks passed. Then months.

The Trudeau government’s recently passed Online Streaming Act is moving into its next phase of regulation by requiring podcasters to register with the Canadian Radio-television and Telecommunications Commission

The government claims the regulation will “ensure online streaming services make meaningful contributions to Canadian and Indigenous content.

…

CRTC stated that another ongoing consultation will address how podcasters and those offering video streaming services contribute to Canadian and Indigenous content.

Liberals say the bill will achieve equitable representation among gender, ethnicity, and related “marginalized” groups.

“In terms of diversity and inclusion, one of the goals of the bill is to put diverse and marginalized voices in the spotlight,” said Senator Dennis Dawson of Quebec during the third reading.”

cross-posted from: https://derp.foo/post/276159

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle, instating a barrier for adult heart regeneration1,2. Here, to explore whether metabolic reprogramming can overcome this barrier and enable heart regeneration, we abrogate fatty acid oxidation in cardiomyocytes by inactivation of Cpt1b. We find that disablement of fatty acid oxidation in cardiomyocytes improves resistance to hypoxia and stimulates cardiomyocyte proliferation, allowing heart regeneration after ischaemia–reperfusion injury. Metabolic studies reveal profound changes in energy metabolism and accumulation of α-ketoglutarate in Cpt1b-mutant cardiomyocytes, leading to activation of the α-ketoglutarate-dependent lysine demethylase KDM5 (ref. 3). Activated KDM5 demethylates broad H3K4me3 domains in genes that drive cardiomyocyte maturation, lowering their transcription levels and shifting cardiomyocytes into a less mature state, thereby promoting proliferation. We conclude that metabolic maturation shapes the epigenetic landscape of cardiomyocytes, creating a roadblock for further cell divisions. Reversal of this process allows repair of damaged hearts.

Unfortunately due to the internet rule that says “if there’s a Nazi at a table and 10 other people sitting there talking to him, you have 11 Nazis” all Canadian MPs have now been converted to Nazis themselves and possibly even super Nazis as they didn’t just sit and talk with him they gave him a standing ovation.