Tired: one day you'll have sex for the last time
Wired: One day your balls won't ache because you saw a pretty girl, felt extremely horny, and couldn't find an opportunity to wack off.
Retired: one day some old lady will be giving you sloppy in your wheelchair and you'll blow a load of dust into her mouth
It is the 51st area.
You have to complete the other 50 areas to unlock it