A well-reasoned and thoughtful response, with a clear demonstration of an experienced writer's capacity for nuance.
*Edit: sarcasm aside, my point is that the comic should be interpreted as an indictment of a socioeconomic system which forces people into situations where they must burn themselves up in order to survive. It should not be interpreted as an indictment of Margaret's life choices. Margaret is doing her best in a world that has not provided her the opportunity to really flourish as an individual. To judge Margaret for this is at best narrow minded.

That sounds extraordinarily arbitrary. Who decides what counts as a "level up"? Does that mean if you start as a bacteria you're stuck like that for a few thousand or million cycles? How would you earn enough karma points to level up from being a bacteria? What counts as "deeper and more meaningful lifetimes" if you are a bacteria?