Yes. There is a mod that allows audiointerfaces to be connected directly to RS via asio drivers.
https://github.com/mdias/rs_asio
Tho it is stated that you also need wineasio for linux.
You need some fiddeling to get it working even under windows but once it works its almost perfect.
Try to focus on having a good form. Maybe research how to correctly hold your hands. Strain on the wrist is definitely not good or nomal. Try t hold it a natural as possible.
Bigger hands make it easier to play notes far apart. But as someone with small hands aswell it is not impossible by anymeans. You definitely have to improvise when some tabs expect you to play notes 4 frets apart but it should not come with hurting wrists.
Try to get feel how you can hold your hand naturally focus on playing easier sheets without straining your wrist.