It is so wild reading how other people react to stimulants like caffeine. The first and only time I've ever felt anything even resembling what I hear more typical people talk about feeling was this one time in college. I get migraines and one of the only things that help them besides closing my eyes and attempting to cease being conscious is caffeine.
In those days the thing that worked best for my migraine was to toss back 800mg of ibuprofen and chug an entire can of Java Monster. Usually I start to feel some relief from the pain in about 20 minutes. At worst, I wouldn't feel anything at all if it was a really bad migraine and downing a second energy drink would usually take care of it. This day was probably one of the worst migraines of my entire life and I ended up chugging 3 cans in about an hour.
Now for someone who at this point had never felt anything at all from literally any amount of caffeine before, suddenly feeling my heart rate spike and starting to feel jittery was an utterly terrifying experience. I ended up giving myself a panic attack and calling my Mom thinking I'd messed up big time and I was about to die of a heart attack or something. In reality my heart rate was only a little elevated and it was a tiny case of the jitters, but being someone who had never felt anything from caffeine before it scared the crap out of me.
That's some lore I've never heard of. I've never heard of this "human domestication guide" you speak of. Is it something you'd recommend?