this post was submitted on 21 Mar 2026
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Global News

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The largest review of medicinal cannabis to date found it doesn’t effectively treat anxiety, depression, or PTSD—despite millions using it for those reasons. Researchers warn it could even make mental health worse, raising risks like psychosis and addiction while delaying proven treatments. Some limited benefits were seen for conditions like insomnia and autism, but the evidence is weak. The findings are fueling calls for stricter oversight as cannabis use continues to rise.

Study: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(26)00015-5/fulltext

Archived version: https://archive.is/newest/https://www.sciencedaily.com/releases/2026/03/260319044656.htm


Disclaimer: The article linked is from a single source with a single perspective. Make sure to cross-check information against multiple sources to get a comprehensive view on the situation.

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[–] MantisToboggon@lemmy.world 71 points 1 week ago (2 children)

It doesn't fix anything, you just don't care as much.

[–] DarrinBrunner@lemmy.world 63 points 1 week ago* (last edited 1 week ago) (1 children)

Right, this does depend on the criteria for successful treatment.

No one questions that pain killers are an effective treatment for pain, though they do nothing to cure the cause of the pain.

[–] bearboiblake@pawb.social 7 points 1 week ago* (last edited 1 week ago) (1 children)

Depends on the painkiller, tbf, I think there's a Cochrane review that finds no evidence to support that paracetamol/acetaminophen is an effective medication for most types of pain, if I remember correctly.

[–] Town@lemmy.zip 10 points 1 week ago (2 children)

What I've seen is that Tylenol is moderately good for fever and headaches, but not for injuries, joints, cuts and abrasions, etc. For those you want an anti-inflammatory, like naproxen or Ibuprofen.

[–] HeyThisIsntTheYMCA@lemmy.world 6 points 1 week ago (1 children)

Thank you. I still have some MDs who rely on that outdated study and try to convince me that I should chew willow bark

[–] some_kind_of_guy@lemmy.world 3 points 1 week ago

That's just aspirin with extra steps

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[–] UnderpantsWeevil@lemmy.world 33 points 1 week ago* (last edited 1 week ago) (1 children)

"Huge study reveals ibuprofen doesn't eliminate pain, just the sensation of it"

Oh okay, I guess I should stop using it then?

"Well, maybe... We need to do another Huge Study to confirm"

[–] otter@lemmy.dbzer0.com 3 points 1 week ago

This time, with dabs.

[–] bearboiblake@pawb.social 65 points 1 week ago (2 children)

Weed helped me not kill myself while going through a mental breakdown with the most severe traumatic flashbacks and dissociative episodes I have ever experienced in my life. I wipe my ass with this study.

[–] fiat_lux@lemmy.world 73 points 1 week ago* (last edited 1 week ago) (3 children)

It's not the study that's the problem here, the study clearly examined it "as the primary treatment". This is a common science media failure, they've conflated "primary treatment" with "helps", and that is not the same thing at all.

Crutches aren't the "primary treatment" for a broken leg either, but they do assist recovery by allowing someone to not use the broken leg. I'd suggest cannabis plays a similar role, it gives people the distance from the pain and further injury that they need for actual recovery, which sounds like it could describe your experience.

[–] CaptainSpaceman@lemmy.world 4 points 1 week ago

Cannabis is sychoactive and allows for deeper introspection to anyone attempting to reconcile their mental health.

It may not be a panacea, but it is very much a great tool in the arsenal of mental health.

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Same, if it wasn't for weed I probably would have punched my own ticket years ago. I've been off it for a few months studying for a drug test and yaboi needs a bong rip.

[–] ryannathans@aussie.zone 45 points 1 week ago* (last edited 1 week ago) (10 children)

There were six studies included on anxiety with a total participant count of ~350... What a pathetic attempt of a review

Only 123 participants for PTSD and ONE study included

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[–] rants_unnecessarily@piefed.social 33 points 1 week ago* (last edited 1 week ago) (2 children)

It's not a "cure" medicine, it's a "relief" medicine.

Like painkillers.
They don't heal, they help lessen the negative effect of the illness to help while healing.

We already know this, stop twisting study results to sound like there's no positive side of cannabis.

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[–] turdburglar@piefed.social 29 points 1 week ago (2 children)

well, that’s just like, their opinion, man.

And didn't pass peer review

[–] Laser@feddit.org 26 points 1 week ago (4 children)

Was cannabis ever a serious contender for these issues? I always considered a painkiller and against loss of appetite, but nothing psychological.

delaying proven treatments

Good luck getting treatment for depression here in a timely fashion, I think with the latest changes, people need to wait about a year for an appointment. Situation is bleak, can't blame anyone getting a bit of relief

It helps for gastro stuff (I haven't paid too much attention to which, just I'm the patient they use to point to as "look! Use it for gastro" and cannabis treats all my gastro diseases). Its about time for my five year check in with the lady who does the cannabis CPE so we'll have plenty to talk about if you want me to ask, just give me like six months to both visit and gather research.

[–] apotheotic@beehaw.org 2 points 1 week ago

I think the point is that if it is the treatment given to you by your doctor without it being a stopgap, then that is delaying proven treatments. If you use it as a stopgap then that's beside the point

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[–] Omgboom@lemmy.zip 26 points 1 week ago

I mean this is obviously anecdotal, but it helped me tremendously through some of the worst trauma I have ever encountered. I don't really give a shit what any study says.

[–] olafurp@lemmy.world 16 points 1 week ago* (last edited 1 week ago)

To be fair, the population of this meta analysis is severely underpowered to assess whether there is an effect for rare/semi-rare conditions. (population is couple of hundred in most areas) and it shows in the confidence intervals. Wouldn't exactly call this a "huge" study.

A better title would be "Study unable to determine if cannabis helps or hurts anxiety, depression, or PTSD because of lack of data" which sounds less glamorous.

[–] rosco385@lemmy.wtf 16 points 1 week ago (1 children)

I don't think weed helps my anxiety, but it does help with the side effects of the anti-anxiety medication.

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[–] dohpaz42@lemmy.world 16 points 1 week ago

Well, speaking for myself, it most certainly helps with my anxiety and depression. So they can stuff it for all I care.

[–] Kalothar@lemmy.ca 14 points 1 week ago (1 children)

Here’s the findings and interpretations from the paper

Findings

54 trials were identified for inclusion (2477 participants; 1713 [69%] males, 764 [31%] females; median age 33·3 years [IQR 28·1–38·05; ethnicity data not available). 24 (44%) of these trials had a high risk of bias, and the certainty of evidence for most outcomes was low. Our meta-analysis revealed that a combination of cannabidiol and delta-9-tetrahydrocannabinol reduced cannabis withdrawal symptoms (SMD –0·29, 95% CI –0·57 to –0·02) and weekly grams of cannabis use (–1·00, –1·69 to –0·30) among those with cannabis use disorder, and a reduction in tic severity among those with tic or Tourette's Syndrome (–0·68, –1·03 to –0·34) compared with placebo. Any cannabinoid type led to an increase in sleep time as recorded by an electronic device (0·54, 0·14 to 0·95) and sleep diary (0·55, 0·01 to 1·09) among those with insomnia. There was a reduction in autistic traits (–0·36, –0·66 to –0·07) among those with autism spectrum disorder. Cannabinoids led to an increase in cocaine craving among those with cocaine use disorder (0·69, 0·22 to 1·15) compared with placebo. There were no significant effects on outcomes associated with anxiety, anorexia nervosa, psychotic disorders, post-traumatic stress disorder, and opioid use disorder. There were insufficient data to meta-analyse studies of ADHD, bipolar disorder, obsessive-compulsive disorder, and tobacco use disorder. There was an absence of RCT evidence for the treatment of depression. Meta-analysis revealed higher odds of all-cause adverse events (OR 1·75, 95% CI 1·25 to 2·46) among those using cannabis versus control group (NNTH=7) but no higher odds of serious adverse events or study withdrawal.

Interpretation

There was some evidence that cannabinoids can reduce symptoms of cannabis use disorder, insomnia, tic or Tourette's syndrome, and autism spectrum disorder, but the quality of this evidence was generally low. Cannabinoids were associated with a greater risk of any adverse events but not of serious adverse events. Overall, there is a crucial need for more high-quality research. Given the scarcity of evidence, the routine use of cannabinoids for the treatment of mental disorders and SUDs is currently rarely justified.

[–] rants_unnecessarily@piefed.social 9 points 1 week ago* (last edited 1 week ago) (1 children)

Overall, there is a crucial need for more high-quality research.

I think this is the main conclusion here.

[–] olafurp@lemmy.world 2 points 1 week ago

Yeah, even the ones where an effect was found have a very low GRADE score (framework for assessing whether conclusions of studies should be used as guidelines) that is affected by risk of biases, directness of evidence, consistency and publication bias.

[–] bulwark@lemmy.world 13 points 1 week ago (5 children)

And might I ask who is funding this study and how are they being paid for by big pharma?

[–] BrikoX@lemmy.zip 9 points 1 week ago

Declaration of interests

WH and MG have received consultation fees from WHO. WH has received payment for expert testimony on the risks of cannabis use. MG is an appropriate member of the Medicinal Cannabis Expert Working Group, Australian Department of Health, Ageing and Disability. MG has received funding from the Therapeutic Goods Administration for independent evidence reviews on medicinal cannabis. All other authors declare no competing interests.

Acknowledgments

JW and ES are supported by a National Health and Medical Research Council (NHMRC) investigator grant awarded to ES (GNT2017346). MG is supported by a NHMRC Postgraduate Scholarship (GNT2030765) and Monash Graduate Research Excellence Scholarship. JL, MT, and GC are supported by NHMRC investigator grants. TPF was funded by a UKRI Future Leaders Fellowship (MR/Y017560/1).

[–] UnderpantsWeevil@lemmy.world 6 points 1 week ago

Plenty of Big Pharma money in producing and distributing cannibas in various forms. We've seen thousands of patents filed since legalization began in earnest in 2015

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[–] HubertManne@piefed.social 8 points 1 week ago (1 children)

I swear not to long ago I saw the opposite conclusion to some studies on mental illness and drugs.

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[–] mountainbear49@programming.dev 6 points 1 week ago (1 children)

Fascists have been robbing people at gunpoint in their own homes with approval from a serial killing billionaire monopolist state and that article talks about pseudoscience, non-verifiable, self-report based terms like feelings of anxiety, depression, and PTSD. Facts have shown that POVERTY causes anxiety, depression, and PTSD. POLICE STATE ARMED ROBBERIES CAUSE ANXIETY, DEPRESSION, AND PTSD. They're more likely to happen to people on the antagonist side of the MERCK, PFIZER, GSK MONOPOLY DRUG CARTEL. That is a fact about cannabis possession, cultivation, usage, and sale. Another relevant fact about this study would be the shadow network of BIG PHARMA serial killers with residence addresses somewhere near readers of that article and bank accounts in 0-tax jurisdictions of the likes of Panama, Luxembourg, etc. that funded putting that pile of feces into a format that looks like a scientific article. In the meantime, those unethical bastards have been selling drugs of the likes of opioids, benzodiazepines, etc. from inside hospitals near the readers of that article, drugs that have killed tens of thousands if not millions of humans per year.

P.S. That article totally omits to even acknowledge the variety of types of cannabis with widely different molecular composition profiles.

P.P.S. That article also omits to acknowledge that fact that research on cannabis consumption therapy has been happening outside the fascist states of the american-european colonial (and racist) empire and their ‘universities’ (sites of propaganda) because of a little thing called a decades-long illegal criminalization of the non-violent behavior of personal choice of consumption of a plant flower with numerous therapy applications growable with a small budget in approximately any house.

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[–] Kwakigra@beehaw.org 5 points 1 week ago

There aren't any drugs that resolve anxiety, depression, or ptsd on your behalf with nothing else. The most any drug can do is reduce feeling these things while they're active so that the causes of the feelings may be addressed with lifestyle and cognitive changes.

Drugs are a temporary shelter from the raging storm of these issues while you re-build or build up in the first place a real shelter to experience the world from in peace and comfort. The temporary shelter blows away when the drugs wear off, and to rely on a temporary shelter permanently is no solution. That being said, plenty of people without any shelter at all don't survive. Drugs help, but they don't fix the problems they provide temporary relief from, you must solve those problems.

Like the study said, there needs to be more specific research in a controlled environment of these substances being used in coordination with established therapies and procedures. I have personal anecdotal experience of positive outcomes with cannabis in a robust framework addressing these issues beyond chemical means. Importantly, I may not have survived without the option to put the overwhelming desire to opt out of this planet on hold for a few hours at a time by briefly regaining my ability to feel pleasure. My psych wanted to try ketamine for this purpose, but I'm a lot more comfortable with cannabis.

[–] Iconoclast@feddit.uk 5 points 1 week ago

I was about to come tell how that has not been my experience at all but then I realized I read the headline wrong.

[–] etherphon@piefed.world 4 points 1 week ago

Well this study doesn't mention psychic pain or spiritual warfare so it's clearly hogwash.

[–] GreenBeanMachine@lemmy.world 3 points 1 week ago

FUCK YOUR PATHETIC PROPAGANDA!

[–] WraithGear@lemmy.world 3 points 1 week ago

i don’t recall that weed was ever used for those things, other then just as a copeing mechanism, i think the argument is that it was better then the other narcotics by a country mile.

unless you are talking about charletons, but like we got people saying magic rocks cure cancer so like why would we need to validate their nonsense?

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