But none of my mice or keyboards work. They'll work briefly for a few seconds and then stop. Nothing works to get them going again forcing me to shut down yet again.
This sounds like there's a hardware problem with either the motherboard or CPU, or possibly the power supply. What motherboard model do you have? Is it one of the Asus models with a backup UEFI/BIOS storage? Does it have one of those 2-digit error code displays?
Is the failure with USB peripherals true for both the fixed USB ports on the back and front USB ports connected via one of the headers? Is it true for both USB 2 and 3 ports?
It's possible that a bad component is shorting a signal on your board.
To troubleshoot:
- Strip everything from the motherboard except for the CPU and the PSU connection. Yes even the RAM. Disconnect all external cables.
- Connect your monitor to one of the motherboard video outputs (not the GPU, that should be removed).
- Connect a keyboard to a USB 2 port on the back of the motherboard.
- Power on the motherboard. Does it POST? Can you interact with the UEFI interface?
- If not, don't panic yet - some boards will POST without RAM and some won't. If yours did not, then insert one RAM stick in the first slot and try powering it on again. We want to define what the bare-minimum startup configuration is.
- Is it behaving any differently? Does the keyboard continue to work, or does it stop working after awhile like before?
- If everything seems OK at this point, reinstall your OS hard drive and test again.
- Continue re-adding components one at a time and testing between each until failure happens.
The goal is to isolate the source of potential problems. You have to do it systematically. Rushing will make the troubleshooting worthless. Take notes.
When you have a moment, a list of the system hardware would be helpful. Also if you have the paper manual for the motherboard get it out.




