this post was submitted on 18 Mar 2026
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Hello gals and pals, I know this may seem abstract and "could never happen" and as most people around me say "collapse is a slow process so you'll have time" but as the Seneca effect has shown - that is usually not true - collapse can and mostly likely will be much faster than we imagine.

And considering geopolitical tensions and the fact that most hormone precursors are made in China I can see the supply drying up almost entirely

I guess my question is - how are you preparing?

For me community is a massive one - learning where to get blood work done outside the system, how to diy, how to get in touch with homebrewers - but at the same time I've not found anyone who actually makes hormones from scratch - most still mix existing precursors into injectables.

I've though about storing pills and making them into stickies ~~but I still doubt they'd last more than 5 years even if stored in ideal conditions.~~ on further research it appears pills could retain 50% or more of their potency for 15-20 years if stored in extra vaccum sealed packaging in a cool dark place

And I know the HRT pharmaceutical business is much bigger than just trans people but AFAIK very few cis people cannot live without exogenous hormones as most produce at least some by themselves - which I dont think is the case if you're trans and have been on HRT for years/decades (not to mention after bottom surgery) - so I can see how their production can get deprioritised in favor of much more critical things like insulin for example.

How are you dealing with all of this?

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[–] dandelion@lemmy.blahaj.zone 15 points 1 week ago* (last edited 1 week ago) (1 children)

If the global supply chain collapses, I am more worried about famine, looting of homes & violent crime, mass migrations, etc. - I will be one of many to perish in such a calamity. Do not get into your head that as an individual there is anything you can do to suitably prepare for or insulate yourself from such extreme disasters. We survive or die together.

[–] zeezee@slrpnk.net 5 points 1 week ago* (last edited 1 week ago) (1 children)

100% agree - still I don't think disaster events will be completely overnight but more so increasingly harsher reductions in quality of life - if we get to fully cataclysmic events then yeah it doesn't matter

but I feel different things will disappear at different rates - food and other necessities will be prioritised but hormones probably not as much - which is why I'm focusing on community as well - I guess my main point was more so as a community what can we do?

like does it make sense to think more about how vital medicines like hormones (including insulin) can be brewed in local bioreactors?

I know https://fourthievesvinegar.org/ is a thing but I'm not well enough versed in biochemistry to do much. has anyone tried anything like this with their network?

[–] dandelion@lemmy.blahaj.zone 7 points 1 week ago* (last edited 1 week ago)

I'm not as confident as you that drugs and hormones won't be prioritized - places like California are already stockpiling HRT, for example.

For context, our lives are fragile and there is not much we can do about that. Most of us are poor, many of us are homeless and/or unemployed.

Already under current conditions probably most of us struggle to ever get to the point of transitioning, let alone access to care. Many of us die before or after. It's definitely better than it used to be, but it's good to remember that the current conditions are still not ideal for most of us, so we don't despair or forget that all moments are times of adversity for us and that we have to figure it out no matter what changes (for better or worse).

So, for the privileged minority with the resources to do so, there are plenty of options:

  • stockpile years of medication so that you can ride out a temporary shortage in HRT
  • stockpile raws & buy the equipment for a home lab, so you can compound your own medication
  • get access to surgery so that your body won't detransition without access to HRT
  • get passports and citizenship status in other countries so you can move around the world as the geopolitical situation deteriorates
  • keep up a social network so that you know where the diminishing pool of care-providers are, and ideally use social capital to get your care prioritized
  • store your stockpile in various secure places so that it cannot be easily confiscated, stolen, or otherwise lost (e.g. in a single house fire)

We absolutely depend on industrial systems to manufacture the bioidentical estradiol and to compound it in a safe way.

I think the closest low-tech alternatives were using the urine from pregnant women, and I've heard of using pregnant horse urine (but I have no idea how healthy or effective that is). I think to separate the estrogen from the urine is tricky and probably requires industrial inputs, and getting that estrogen into a route of administration that isn't super wasteful and ineffective (like oral routes) again requires even more refinement and industrial tools.

So, realistically I would say a "primitivist" approach to HRT is not going to happen, in which case it's just about trying to ensure you have privileged access to a dwindling and scarce resource, and then trying to ensure you won't lose that access.

Again, this is all rather individualist in mindset and not relevant to pretty much anyone here - we are not the privileged minority, we are the desperate masses and we should remember that.

[–] ada@lemmy.blahaj.zone 12 points 2 weeks ago (1 children)

I can't produce testosterone anymore, and I've got a few years worth of injections spare. After that runs out, I guess it's menopause time...

[–] zeezee@slrpnk.net 7 points 1 week ago (1 children)

thank you for sharing 🙏

yeah I've actually wondered about this as well and the good news is that QoL seems to be relatively the same between natural and surgically induced menopause (what transfemmes would be most similar to)

tho physical effects seem to be much more severe:

Compared with women of the same age who still had their ovaries, women who were under age 46 when their ovaries were removed were 64% more likely to have arthritis, twice as likely to have obstructive sleep apnea, and nearly three times as likely to have had a bone fracture.

however they do say that if you're on HRT until 50 the risks are greatly reduced

I would also imagine that using expired hrt tablets might help as well since they just become less potent over time and from what I've read estradiol tablets are pretty shelf stable so if stored well could retain up to 50% potency for decades post exp. date - might be worth getting some just in case to vaccum seal and store in a cool dark drawer

[–] dandelion@lemmy.blahaj.zone 11 points 1 week ago* (last edited 1 week ago)

it's worse, and living without sex hormones threatens health in many ways - nobody should expect to just live without sex hormones and feel ok - they will struggle to sleep, experience night sweats & hot flashes, fatigue, their bones will become brittle and be more likely to break. There are also lots of mood problems: depression, anxiety, mood swings, irritability, brain fog & trouble thinking are all common.

It's more extreme for post-op trans folks because their bodies don't produce any suitable amount of sex hormones (whereas in cis men and women, menopause and age comes with waning levels of hormones but not an abrupt end to their production).

A trans man I know who lived without sex hormones for over six months started to have his joints deteriorate and his knees would swell and struggle to articulate. It's awful, and should be avoided if at all possible.

@zeezee Yes I am. We (as a community) should strife for local organizsation. It is apparently not that hard to create injectable estradiol from raw e-powder. And you need only very very little.
Wish there was a workshop or smth for that.

[–] irotsoma@piefed.blahaj.zone 2 points 1 week ago

If that happens, then food and water will be higher priorities. I'm not sure I'd even care to live in a post-apocalyptic society.

I'm more worried about more targeted attacks like the FDA or HHS making it illegal to treat trans patients like many states are testing with trans children to people used to and get the right wing fired up about it as they add adults and move to the federal level. I only hope Canada and/or European countries start offering asylum for trans people when thar happens. But I bet Trump or JD will not hesitate to go to war with the those old allies they've been turning into enemies with their new nukes if they do along with doing the same to fleeing emigrants as they're doing to immigrants right now. But then we're back to probably not worth it to survive in that post apocalyptic world.

[–] premadekrill@lemmy.blahaj.zone 2 points 1 week ago* (last edited 1 week ago) (1 children)

Chinese transwoman here, and I share similar concerns.

On the black market in China, the main hormone medications available to transgender women are Progynova from Thailand, Androcur from Turkey, and Progynon from Japan. Due to the deterioration of China-Japanese relations following Takaichi Sanae’s appointment, the price of Progynon skyrocketed a while back; and because of the Turkish government’s recent anti-LGBTQ+ policies, I’ve heard that transgender people in Turkey are also having a hard time getting Androcur—though it’s still available on the black market here, I’m not sure how the situation will develop in the future; Although the military conflict between Thailand and Cambodia a while back ultimately did not escalate, it still caused me great concern. I do not want anyone to die in war anywhere, at the same time, due to China’s strict gatekeeping policies regarding bottom surgery, Thai hospitals remain the only option for many Chinese transgender individuals who lack parental support to undergo surgery and change the gender on their IDs. Some people are also worried that if war breaks out in the Taiwan Strait, China might adopt even harsher anti-LGBT policies like Russia’s. However, in such a scenario, medication probably wouldn’t be the top priority anyway.

Regarding homemade medications, after China issued a ban on the online sale of hormonal drugs in late 2022, some transgender individuals, fearing further restrictions, began purchasing industrial-grade estradiol to experiment with. Due to safety concerns, homemade injections and oral medications have been met with resistance within the community. However, some people still produce estradiol gel, believing that hormones absorbed through the skin allow for more impurities to be filtered out.

[–] zeezee@slrpnk.net 2 points 1 week ago (1 children)

Thank you so much for sharing! That sounds genuinely terrifying - hope you're staying safe and are managing to get your medicines safely 🙏

I'm not sure you had a chance to look at the stickies zine I linked in the original post but a major benefit is that you can get:

10 months’ worth of stickies for every month’s worth of tablets

This is only 5x if you're already using tablets sublingually or buccal but it's definitely an improvement either way

I've personally not tried it yet but you can read up on reddit and a lot of people swear by it (you can also up your dosage and do mono if you're finding it hard to get ahold of androcur/anti-andros)

but yeah I've also heard of a diy lab mixing e-powder into gel and injectables in France - but usually people here find LQBTQ+ friendly professional labs that are willing to test those diy mixtures for purity - I'm guessing that's not really an option?

again thanks so much for sharing 🫶

Thank you for sharing the link; I think it will be very useful in many situations. At the moment, I’m not familiar with the stance of professional labs in China or the relevant procedures, and I don’t seem to have come across any cases where people have sought their assistance for testing. Since I’ve noticed that more and more people are choosing to make their own gels, perhaps trying to arrange for testing is a good suggestion.