Yep, I've dabbled in Guix before but was put off by the smaller/more outdated repository (according to repology, it has improved a lot lately but it's still nowhere near nixpkgs) and the official non-support/second-class support for non-FOSS software (which, as much as I try to avoid it, is still a necessity in my day-to-day). The ecossystem being smaller is also an issue, but I'm not afraid to get my hands dirty and contribute some of the glue myself if necessary. Something else is FSF's reliance on mailing lists and IRC; I get sticking with FOSS, obviously, but aren't there more modern/ergonomic FOSS alternatives that suit their needs? The move from Savannah to Codeberg for the repositories was a welcome one and I hope they would follow with the rest of their platform, but oh well.
Regardless, the time has come to make the jump. I can no longer afford to keep supporting a distribution being blatantly hijacked by far-right defense sector actors (for a far-right regime and their far-right allies). I hope Guix will treat me as well as I intend to treat it. :)
And I seriously pray that it is more resilient to hostile takeovers by fascists, since, to my knowledge, there are no other Linux distributions in the "declarative, reproducible, immutable" family/paradigm. It's just NixOS and Guix. So Guix it is. I got too comfortable with the guarantees this model gives me to ever go back to more standard distros, I'm afraid.