This is much older than the posted date, so the terrain was way different, and the ecosystem was way different.
Caveat: I worked on the packaging projects he is discussing.
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His whole thing was wanting to package things much more like MacOS at the time. It was pretty foolproof from a user's perspective, but terrible for developers.
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AppImage at the time was essentially the same thing as he was aiming for, but it has some security drawbacks. He hated them. He wanted to be them.
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Post this talk, Flatpak came out, which is an improvement on the AppImage premise, but has layers, so uses less disk...in theory. He hated it.
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Once the rise of containers came along, and everyone was (still is) generally using them wrong, he had a fucking meltdown and tried to revive another packaging project which he quickly gave up on.
I mention all of this to say: don't just listen to what he's saying and take it at face value. Sure, he's a legend, but he's just a developer. He wants the unattainable technical solution just like every other developer. There is no ONE right answer here, and things now are way better than when this was recorded maybe 10 years ago. WAY better.