I've done renegade runs dozens of times where I'm a dick to most people, but my crew is hard. I've only successfully done it once where I was a dick to everyone. At the end all but I think grunt survived 2 or something. Avoided any loyalty missions where I couldn't see value in it. Mission always comes first. It was horrible. It was the saddest. Party. Ever.
Sigh-Fi
A generalist Sci-Fi meme community.
Only exception to me is Ashley, no room for spacists on my ship, though she does totally change that tune by me3
There's definitely some things I will never do regardless,
Tap for spoiler
Not curing the Genophage and lying to Wrex is one, will never kill Wrex either.
Ashley's poetry is worse than her space racism. Don't get me wrong it's a close number 2, but I always want to punch her after she recites the poetry
Every time....then it's time to reload and make all the exact same decisions as every other playthrough again.
I love how Pathfinder let's you turn off the text that indicates what each dialogue option gives you. Looking over your alignment history can be interesting after a few dozen hours.
And it ideally stops you from just picking the "usual" options every time.
Not played Mass Effect, but this is how my only try at a stormcloak run in Skyrim ended. It's not really a "good run vs evil run thing" given the factions involved, but when you do the stormcloaks the whiterun jarl shames you for betraying him and invading his city and I didn't really feel like keeping on with that plotline after it.
Frankly all the factions in Skyrim suck, that's why every playthrough ends up murderhobo