this post was submitted on 30 Jul 2025
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What are some SNDRIs you're aware of? (lemmy.world)
submitted 3 days ago* (last edited 3 days ago) by cheese_greater@lemmy.world to c/asklemmy@lemmy.world
4 comments fedilink hide all child comments
 

Serotonin-Norepinephrine-Dopamine Reuptake Inhibitors

  • Cocaine
  • Possibly venlafaxine (at higher doses, just learned of this)
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[–] Level9831@lemmy.world 2 points 2 days ago* (last edited 2 days ago)

Bupropion is a NDRI. Then you would have to add on an SSRI. However, 2 antidepressants aren't usually prescribed together.

Edit: dextromethorphan/bupropion (brand name Auvelity). The dextromethorphan hits multiple targets including NMDA and sigma 1, but technically has some inhibition activity to SERT. I am unsure how strong that activity is, whether it is dose dependant, if its an active metabolite etc. Also should point out that nowhere on the manufacturers website do they talk about using the dextromethorphan to hit serotonin. According to the website, the true mechanism of action of Auvelity for treating MDD is not well understood.

Edit2: check out this page. Gives more info and some references. Apparently fairly strong against SERT. [(https://tmedweb.tulane.edu/pharmwiki/doku.php/dextromethorphan)]

[–] bigfondue@lemmy.world 3 points 3 days ago (1 children)

https://en.wikipedia.org/wiki/Tesofensine

It's under trials for obesity. It has a half-life of like seven days. I've seen it for sale online, but it was quite expensive.

[–] cheese_greater@lemmy.world 1 points 3 days ago (1 children)

Would it literally be dosed weekly az opposed to daily?

[–] bigfondue@lemmy.world 2 points 3 days ago

No I think the dose used in studies is like 0.5-1.0mg once a day.