RNACap uses pH-sensitive coatings and pressure-triggered release membranes to remain intact in the stomach. Contents are released in the intestine in response to neutral pH and peristalsis.

Nanoparticles were formulated using G0-C14, PLGA, and PEG-lipid components for mucus penetration and endosomal escape. A 5% DMPE-PEG formulation showed optimal transfection in vitro.

oh man. as a needlephobe. please. please. please.

[–] pressedhams@lemmy.blahaj.zone 8 points 5 days ago

I just saw a similar article about using this delivery method for insulin. I’m just some plebeian but it’s all very interesting!

[–] tenchiken@lemmy.dbzer0.com 2 points 4 days ago (1 children)

Thanks for the summary!

[–] HubertManne@piefed.social 3 points 4 days ago

no prob. If I read the article I usually try to paste what I feel is the most relevant bit and once in awhile I will do the whole thing or if its too long I will add a comment encouraging people to read the article if its good enough.