Linux support for NPUs is still evolving but making progress. Intel's NPUs can be used with their OpenVINO toolkit (works on Ubuntu/Fedora), and AMD has their ROCm platform for their NPUs. You can run stuff like Stable Diffusion locally using these - check out Automatic1111 which can utilize NPU acceleration. If you're looking for the best power efficiency for AI workloads, you might want to compare some power stations on gearscouts.com to keep your system running during longer inference sessions.
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I believe some projects using OpenVino and ONNX can make use if the NPU. Maybe the generative AI plugins for GIMP and Audacity. But it's not a lot.
Most distros with have Arm and x86/64 versions so it is quite likely it can.
Not sure what the state of the Risk-v instruction set is.
But without knowing the device itself there is limited information we can give you.
This isn't an Arm vs x86 thing though, newer CPUs pretty much across the board from Intel/AMD/Qualcomm have an additional NPU that they use for AI acceleration.
As for support, you might be able to use them? It probably depends on the exact software but they might be able to be used for local LLMs. It's not exactly clear what practical uses they have even on Windows so that doubly applies to Linux just because it's more niche.