Start by ensuring you are following GenP Guides and read the Troubleshoot Section.
For most users, simply patching (including the required unpack for Premiere Pro beforehand) removes all non-AGS-related pop-ups.
In such cases, you shouldn’t need modified hosts or firewall settings either.
For some users, simply patching doesn’t always work, in such cases, you can make use of WinTrust for the specific app.
By trusting the required app and restarting, the change should eliminate any non-AGS-related pop-ups.
Simply repatching multiple times won’t help either, especially with Premiere Pro, as it needs to be unpacked before patching to work properly.
Also, patching only works once; repatching after the initial patch won’t overwrite the existing one.
When you’ve patched correctly or used WinTrust, GenP should have removed all non-AGS-related popups, and you can run Premiere Pro without the need for modifying hosts or using a firewall.
If the issue still persists, you can revert back to the previous methods of modified hosts or firewall rules, though they should no longer be necessary.
You may still encounter AGS-related pop-ups, like the Adobe Genuine Service popup, although this is easily removed via another method, as mentioned in Troubleshoot Section.