science

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. This study shows that metformin induces the formation of hunger-reducing metabolite N-lactoyl-phenylalanine (Lac-Phe), a byproduct of muscle fatigue and an amino acid called phenylalanine, found after heavy exercise.

https://www.nature.com/articles/s42255-024-00999-9