this post was submitted on 29 Feb 2024
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Microbial pathogenesis here. This one's a fun one for me, especially since COVID revealed just how illiterate the average person is about diseases. Here's a couple that I think should be common sense
Not all bacteria cause disease. In fact, very few bacteria cause disease. Many bacteria are even helpful to us, so you should really weigh the pros and cons of taking antibiotics if you're considering using antibiotics.
Antibiotics don't work against viral infections. You're getting all the downsides of killing helpful bacteria and getting none of the benefits
Do not blindly trust your immune system. Your immune system works 100% of 50% of the time. Many white blood cells take the philosophy of murdering everything in sight just to be safe. This can and often does include killing important cells in your body that just happen to be nearby the site of infection. Even if you survive the infection, you will be weakened as a result. If you can avoid getting sick in the first place, avoid getting sick.
Vaccines work. I don't really know what else to say about this one.
Viruses and bacteria aren't hard to kill. There's many compounds that can kill viruses and bacteria. But humans aren't hard to kill either. The tricky part is figuring out how to kill viruses and bacteria while also keeping the human alive. Basically: don't drink bleach. It will kill your bacteria or virus but it'll kill you too
E. coli isn't a usually bad bacteria. Actually, it's a very important bacteria that helps us digest food. The reason it gets such a bad reputation is because it's relatively hard to kill, which makes them a very good way to quickly check if there's a possible food/water contamination. In other words, the presence of E. coli itself isn't bad, but finding E. coli does suggest that there might be other, more dangerous bacteria.
DO NOT EAT MOLDY FOOD. The fuzzy part that you see is just the fruiting body of the mold, analogous to a flower on a plant. The real body of the mold is an invisible network of roots that tunnel through the core of the food. Even if you cut off the fuzzy portion, you're still eating most of the mold.
Could you say something about why it’s bad to eat moldy food, and why it’s bad to kill the good bacteria in your body? I know your intestines can function less well, is there anything else?
Regarding moldy food, it's because you're taking a gamble on what exactly the mold is. There's many types of mold, and some can produce very toxic compounds. Eating the mold can poison yourself. Of course, if you know that it's a safe mold, then you can eat it (that's how cheese making works). But as with all things in microbiology, things tend to be complicated very quickly, and it can be pretty hard for amateurs and even professional microbiologists to accurately distinguish between safe and unsafe molds.
With regards to killing helpful bacteria, you are correct that one of their uses is that they help improve the efficiency of digestion. This is a very young and growing field (and also not entirely in my field of expertise), so many things I say might be outdated. The second most obvious downside to killing helpful bacteria is that they prevent actual harmful bacteria from growing out of control. There are several bacteria (in particular, C. dificile) where taking antibiotics actually makes the infection worse, since the antibiotics kills off the helpful bacteria that were helping to contain the infection.
Scientists also have found semi-recently that bacteria in your intestines have an incredible amount of control over you as a person. Your body even has a sort of hotline that connects from your intestines directly to your brain, called the vagus nerve, and the bacteria in your intestines use this to communicate with your brain. For instance, scientists have found that the type of bacteria in your gut can influence the onset and severity of autism symptoms. One current hypothesis for autism is that the body, during development, somehow messes up the composition of bacteria in your intestines, and that in turn messes up the development of the brain. I seem to recall reading papers that linked bacteria to other neurological diseases and disorders, but I don't remember completely.
Another is that the bacteria are known to be linked to obesity. Scientists have found that if you give 2 people the exact same foods in the exact same amounts, one can develop obesity and one won't. Whether someone develops obesity or not is highly predictable based on the composition of the bacteria in their intestines. As a matter of fact, scientists have even found that if you replace an obese person's bacteria with bacteria taken from a healthy person, then the obese person will begin to lose weight, even if that person hasn't changed anything else.
The bacteria in your intestines are also known to be in constant communication with your immune system. I believe the immune system uses the bacteria in your intestines to train when you're young. But this back-and-forth extends well into adulthood. Scientists found that bacteria can control the development and activity of white blood cells. That, of course, leads to differences in things like fighting off infections and killing cancers.
The bacteria in your intestines are incredibly important, and we're only just now beginning to understand what they do for us. That's why I say that you have to weigh pros and cons. If you think you'd be fine without it, I recommend not taking antibiotics. But if the infection is severe, then it's worth dealing with the downsides. Talk to your doctor if you're unsure - he probably knows more about what situations are severe and which aren't. But what you definitely don't want to do (which I know many people tend to do) is to pressure the doctor into prescribing antibiotics. Antibiotics aren't a wonder drug, and people shouldn't be immediately jumping to antibiotics as a solution to their infections
Thank you! That helped to give some more insights into why exactly it’s bad, I knew it was but not sure through which processes. My doctorate was in neuroscience, and around the time I left academia, the gut microbiome-brain axis research was really starting to ramp up. It was the big buzzword at the time. But since I left to work in the industry, I haven’t really kept up with the developments in the gut microbiome neuroscience field.
I really wish they’d find a better way to treat chronic cystitis than through antibiotics, but so far it’s the only treatment that really reliably helps.