this post was submitted on 20 Dec 2023
472 points (94.7% liked)

science

20873 readers
379 users here now

A community to post scientific articles, news, and civil discussion.

rule #1: be kind

founded 2 years ago
MODERATORS
 

In trials

you are viewing a single comment's thread
view the rest of the comments
[–] evatronic@lemm.ee 29 points 2 years ago (1 children)

T1 diabetes here. A cure is just 5 years away...

They told me, when I was diagnosed in 1992.

[–] Lmaydev@programming.dev 17 points 2 years ago (1 children)

It always 5 years if properly funded. It's never properly funded so always 5 years.

They are testing an artificial pancreas currently. The cost is the issue as always.

[–] AnyOldName3@lemmy.world 7 points 2 years ago* (last edited 2 years ago)

We can genetically engineer bacteria to mimic the missing pancreatic cells, and it's not too different to the way most insulin is produced as all that's new is the system to stop producing insulin when blood sugars are already low enough. However, if you put them in a person, the immune system attacks the bacteria, so they need isolating. To do that, we need a membrane that lets sugar in and insulin out, but doesn't let antigens or live bacteria out, and doesn't let immune cells in. Even if the bacteria are held in place, if immune cells can get in, it's no better than a pancreatic transplant as you'll still need immunosuppressants, and they're generally worse than dealing with type one manually. Development of the membrane keeps hitting unexpected hurdles, so artifical pancreases are still unable to start trials, and then they might take a decade.

There are other approaches, e.g. using electronics to control photosensitive insulin producing bacteria, but they don't have any advantages (the membrane still has to let sugar in so the bacteria can eat) and have more things that can go wrong.