this post was submitted on 04 Sep 2023
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Science

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Brain's Weight Switch Found: May Let Us Eat What We Want, Finally (neurosciencenews.com)
submitted 2 years ago by will_a113@lemmy.ml to c/science@beehaw.org
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A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

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[–] Centillionaire@kbin.social 23 points 2 years ago (10 children)

Or how about regulate the sugar and salt content in foods? No? More magic diet medications. Got it.

[–] EquipLordBritish@beehaw.org 18 points 2 years ago (2 children)

Given that it may be more likely for us to put up a Solar Shield than curb our fossil fuel usage, I think we are too stuck in a "fix things after the fact" culture than using preventative solutions.

[–] xePBMg9@lemmynsfw.com 1 points 2 years ago

The idea is to enjoy yourself without consequences.

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