this post was submitted on 31 Mar 2026
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[–] Buffalox@lemmy.world 42 points 1 day ago* (last edited 1 day ago) (59 children)

analysed reviews of evidence from animal studies,

I seriously doubt that, because the bases in e-juice were studied thoroughly in the 50's with no such evidence.
And nicotine has obviously also been studied thoroughly, and the nicotine is not considered a major carcinogen in cigarettes, it's mostly compounds created by the burning of the paper and tobacco that cause cancer that is the actual SMOKE in smoking, which vapes do not have, unless the vape is seriously overheated.

I bet that this study is flawed, if it truly shows indication of cancerous effects, I bet it's because they overheat the e-juice, which has the same effect as burning fat on a frying pan. And with the e-juice taste horribly.
Either that or they've used impure products, and not the pharmaceutical quality products that dominate the industry.
If you are a vaper, make sure the nicotine and base juice are both pharmaceutical quality.

However, the review included case reports from dentists who noticed oral cancer in people who had only vaped and who had never smoked.

This is partially based on self reporting, which is the least reliable form of study there is.
Also I've never heard such warnings from dentists?

Unfortunately with these kinds of studies, we have to consider they can either be honestly flawed, but worse than that the studies can be dishonest to attract funding.

[–] kieron115@startrek.website 5 points 1 day ago* (last edited 7 hours ago) (3 children)

afaik the bases of e-juice were studied for ingestion, not inhalation.

edit: i was thinking of diacetyl which is sometimes used as a flavoring additive and caused a bunch of lung injury in the early days of microwave popcorn manufacturing. While looking through these I stumbled upon vitamin e acetate (used as a condensing agent in vape products) and it sounds none to good for you either. https://pmc.ncbi.nlm.nih.gov/articles/PMC6952050/

[–] Buffalox@lemmy.world 5 points 15 hours ago* (last edited 15 hours ago) (1 children)

Then you know wrong, they were studied thoroughly for inhalation too, and were approved and used in kindergartens to prevent respiratory diseases. They are still used in asthma inhalers, and in stage fog machines in rooms crammed with people.
None of the branches that use these compounds very heavily have had problems, and they are still used.

The fact that you are so heavily upvoted just shows that people here are extremely ignorant about the issue, but still feel their ignorant opinion has value.

[–] kieron115@startrek.website -1 points 7 hours ago (1 children)

albuterol inhalers use saline solution as a carrier.

Each milliliter of albuterol sulfate inhalation solution 0.083% contains 0.83 mg of albuterol (as 1 mg of albuterol sulfate) in an isotonic, sterile, aqueous solution containing sodium chloride; sulfuric acid is used to adjust the pH to between 3 and 5. Albuterol sulfate inhalation solution 0.083% contains no sulfiting agents or preservatives.

[–] Buffalox@lemmy.world 1 points 3 hours ago

albuterol inhalers use saline solution as a carrier.

That sounds weird, that is in principle just salt water, and a vapor that is way harder to control. But just because an alternative exist, doesn't mean other options are bad.

[–] Reginald_T_Biter@lemmy.world 4 points 15 hours ago

Actually the bases are safe. They were tested extensively for inhalation in like the 50s or 60s.

[–] MalReynolds@slrpnk.net 7 points 19 hours ago* (last edited 19 hours ago) (2 children)

Nope, PolyEtheleneGlycol (PG) is the carrier in Ventolin inhalers. Glycerine (VG) is something the body knows how to handle because it's the chemical backbone of triglyceride, the most common form of human fat. VG and PG are the usual bases in ejuice.

Valid point for the majority of flavours though (maybe 1-5% by volume), although mint is likely fine and used in some medical contexts and for some reason tobacco flavour is prescribed in Australia, probably because it's disgusting.

[–] kieron115@startrek.website 1 points 8 hours ago

Each milliliter of albuterol sulfate inhalation solution 0.083% contains 0.83 mg of albuterol (as 1 mg of albuterol sulfate) in an isotonic, sterile, aqueous solution containing sodium chloride; sulfuric acid is used to adjust the pH to between 3 and 5. Albuterol sulfate inhalation solution 0.083% contains no sulfiting agents or preservatives.

Seems like they just use pH-adjusted salt water for it? Been looking for more data but I'm having trouble finding anything that isn't behind stupid paywalls.

[–] Buffalox@lemmy.world 5 points 15 hours ago (1 children)

Don't forget the massive fog machines, that are allowed indoor in crowded rooms, because of how safe they are.

[–] kieron115@startrek.website 1 points 8 hours ago (1 children)
[–] Buffalox@lemmy.world 1 points 3 hours ago

Absolutely 100%, even water is toxic. If you drink 4 liters of it in a short span of time, you will die.

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