this post was submitted on 27 Mar 2026
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im interesting in additionally suppressing HPG axis without super high E(can cause mood swings)

what other benefits of prog?

im worried about converting into DHT in liver via oral route(i dont like rectal method.....)

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[–] dandelion@lemmy.blahaj.zone 4 points 6 days ago* (last edited 6 days ago) (6 children)

If you're only going to take it orally, don't bother tbh - it probably won't help you much at all.

I took it for the reason you mentioned - to help suppress testosterone production, and then to help me sleep when my E levels were high when I was using monotherapy to suppress T.

But I only took it rectally, and I only recommend you take it rectally. There's not much point in taking it orally.

[–] erin@quokk.au 2 points 5 days ago (1 children)

is possible to take prog sublingualy?

[–] erin@quokk.au 2 points 5 days ago (1 children)
[–] dandelion@lemmy.blahaj.zone 3 points 5 days ago* (last edited 5 days ago) (1 children)

The article I linked to covers this:

https://transfemscience.org/articles/oral-p4-low-levels/

the t;dl answer is basically no - rectal administration is really the best option.

It's not really a big deal tbh, plenty of medications are administered rectally (or vaginally).

here's the longer answer:

for sublingual there are two problems:

Sublingual progesterone appears to achieve high and more physiological progesterone levels than oral progesterone but has a short duration of highly elevated progesterone levels similarly and necessitates administration several times per day (Wiki; Graph). Moreover, although sublingual progesterone may have been more widely available in the past (Wiki), it is available today only in a couple of Eastern European countries (Wiki).

so:

1. though it raises the blood progesterone levels much better than oral route, the metabolism is too spikey so you don't really benefit from consistently elevated blood progesterone levels, making it somewhat pointless (this is a similar problem with sublingual estrogen)

2. sublingual progesterone is not available for most people, very few will have access to it

The problem with transdermal is that progesterone does not absorb through the skin well, so it doesn't raise blood progesterone levels sufficiently, it's similarly low as oral route:

It is notable that transdermal progesterone achieves very low progesterone levels similarly to oral progesterone and is not a good option for progesterone therapy (Wiki; Hermann et al., 2005; Graph). Progesterone levels with neovaginal administration of progesterone in those who have undergone penile inversion vaginoplasty are likely to be low similarly.

so again, not an option.

The real alternative to rectal is daily injections - which is again impractical not just from a cost perspective, but because injectable progesterone is not widely available.

This is why rectal administration is basically the only reasonable route of administration for progesterone.

[–] erin@quokk.au 2 points 4 days ago (1 children)

Способ применения и дозы 1 аппликация (2,5 г геля), содержащая 0,025 г прогестерона, наносится на кожу молочных желез аппликатором-дозатором до полного всасывания 1-2 раза ежедневно, sorry for russian im lazy to find manufacturer instruction in english it saids to put to breasts

so progestogel can be used only for breasts growth?

[–] dandelion@lemmy.blahaj.zone 2 points 4 days ago* (last edited 4 days ago)

As already mentioned, progestogel, just like oral progesterone, does not sufficiently raise blood progesterone levels. The conclusion is not that progestogel can only be used for breast growth, but instead that it won't successfully help a transfeminine individual raise their blood progesterone to be similar to cis female levels, making it an insufficient route of administration.

It won't work, don't take it - it's a waste of money and time.

Realistically the only option is rectal administration of oral progesterone pills.

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