this post was submitted on 18 Mar 2026
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Hello gals and pals, I know this may seem abstract and "could never happen" and as most people around me say "collapse is a slow process so you'll have time" but as the Seneca effect has shown - that is usually not true - collapse can and mostly likely will be much faster than we imagine.

And considering geopolitical tensions and the fact that most hormone precursors are made in China I can see the supply drying up almost entirely

I guess my question is - how are you preparing?

For me community is a massive one - learning where to get blood work done outside the system, how to diy, how to get in touch with homebrewers - but at the same time I've not found anyone who actually makes hormones from scratch - most still mix existing precursors into injectables.

I've though about storing pills and making them into stickies ~~but I still doubt they'd last more than 5 years even if stored in ideal conditions.~~ on further research it appears pills could retain 50% or more of their potency for 15-20 years if stored in extra vaccum sealed packaging in a cool dark place

And I know the HRT pharmaceutical business is much bigger than just trans people but AFAIK very few cis people cannot live without exogenous hormones as most produce at least some by themselves - which I dont think is the case if you're trans and have been on HRT for years/decades (not to mention after bottom surgery) - so I can see how their production can get deprioritised in favor of much more critical things like insulin for example.

How are you dealing with all of this?

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[–] dandelion@lemmy.blahaj.zone 15 points 1 week ago* (last edited 1 week ago) (1 children)

If the global supply chain collapses, I am more worried about famine, looting of homes & violent crime, mass migrations, etc. - I will be one of many to perish in such a calamity. Do not get into your head that as an individual there is anything you can do to suitably prepare for or insulate yourself from such extreme disasters. We survive or die together.

[–] zeezee@slrpnk.net 5 points 1 week ago* (last edited 1 week ago) (1 children)

100% agree - still I don't think disaster events will be completely overnight but more so increasingly harsher reductions in quality of life - if we get to fully cataclysmic events then yeah it doesn't matter

but I feel different things will disappear at different rates - food and other necessities will be prioritised but hormones probably not as much - which is why I'm focusing on community as well - I guess my main point was more so as a community what can we do?

like does it make sense to think more about how vital medicines like hormones (including insulin) can be brewed in local bioreactors?

I know https://fourthievesvinegar.org/ is a thing but I'm not well enough versed in biochemistry to do much. has anyone tried anything like this with their network?

[–] dandelion@lemmy.blahaj.zone 7 points 1 week ago* (last edited 1 week ago)

I'm not as confident as you that drugs and hormones won't be prioritized - places like California are already stockpiling HRT, for example.

For context, our lives are fragile and there is not much we can do about that. Most of us are poor, many of us are homeless and/or unemployed.

Already under current conditions probably most of us struggle to ever get to the point of transitioning, let alone access to care. Many of us die before or after. It's definitely better than it used to be, but it's good to remember that the current conditions are still not ideal for most of us, so we don't despair or forget that all moments are times of adversity for us and that we have to figure it out no matter what changes (for better or worse).

So, for the privileged minority with the resources to do so, there are plenty of options:

  • stockpile years of medication so that you can ride out a temporary shortage in HRT
  • stockpile raws & buy the equipment for a home lab, so you can compound your own medication
  • get access to surgery so that your body won't detransition without access to HRT
  • get passports and citizenship status in other countries so you can move around the world as the geopolitical situation deteriorates
  • keep up a social network so that you know where the diminishing pool of care-providers are, and ideally use social capital to get your care prioritized
  • store your stockpile in various secure places so that it cannot be easily confiscated, stolen, or otherwise lost (e.g. in a single house fire)

We absolutely depend on industrial systems to manufacture the bioidentical estradiol and to compound it in a safe way.

I think the closest low-tech alternatives were using the urine from pregnant women, and I've heard of using pregnant horse urine (but I have no idea how healthy or effective that is). I think to separate the estrogen from the urine is tricky and probably requires industrial inputs, and getting that estrogen into a route of administration that isn't super wasteful and ineffective (like oral routes) again requires even more refinement and industrial tools.

So, realistically I would say a "primitivist" approach to HRT is not going to happen, in which case it's just about trying to ensure you have privileged access to a dwindling and scarce resource, and then trying to ensure you won't lose that access.

Again, this is all rather individualist in mindset and not relevant to pretty much anyone here - we are not the privileged minority, we are the desperate masses and we should remember that.