this post was submitted on 13 Feb 2026
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The drug is Pramipexole and it has this weird side effect that has been well documented:
From Wikipedia.
This of course does not diminish the suffering of those affected.
Hah, I've been on that for the last 10years or so.
The side effects are really weird as described, and also very subtle if one doesnt pay attention. Pramipexole made it click for me when it comes to understanding how dopamine actually works.
Ive seen studies using it to counter/help cocaine abusers due to its dopaminergic effect, and have myself tried cocaine while on it, and the effect is really diminished rendering it pretty much uninteresting to whoever wants to use it.
Dopamine is truly weird.
That is an interesting experience you described with the use of cocaine. I'm trying to understand this: would you say, while on a dopamine agonist you'd up the dose of cocaine as to reach the same effect when not on it if you'd feel compelled to do so?
There seems to be some cross tolerance, yes. I've never had an experience that would be worth the cost of coke while on pramipexole, at most i got a warm face and a sweaty forhead, it's just wasted money.
I've also tried coke while not on any DA, and can't say the same about that..
The study I'm thinking of tried it to relieve the urge on recovering addicts, with what I remember pretty good results.