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Have a look at 'Carl Sagan's Baloney Detection Kit' here: https://www.openculture.com/2025/09/the-carl-sagan-baloney-detection-kit.html These ideas are 'common sense' to ' people who Quantum for a living'. Immortality - right or wrong- is WAY OUTSIDE what's within the reach of day-to-day science.
Penrose is a talented and knowledgeable guy who's can afford to 'think outside the box' without making crazy claims. The guy who thought up plate tectonics was 'rushed out of the room' for 50 years ... until people realized the value of his idea.
The main points are there in text. If you want to hear more about each point, the YT video goes into them in detail.