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It's a disassociatave. iirc there's similar reports about ketamine too.
Yeah, I had oral surgery maybe ten years ago, with ketamine as part of the anaesthesia. Had a solid six month remission of depression.
That was a literal trip too, though. Coming out of it, I was talking to celestial beings and such lol.
And dextromethorphan, or DXM (the active ingredient in Robitussin). Not clinically proven, of course, unlike ketamine, but a lot of dissociatives seem to have the effect.
Bupropion + Dextromethorphan actually hit the market specifically for depression recently.
I just tried buproprion. It was an expensive sugar pill for me, or might as well have been.
Honestly I feel the same about buspar but some people swear by it. I actually liked the wellbutrin a LOT it just also gave me terrible air hunger. I've wondered if the Dextromethorphan would counteract that.
Lexidrugs (my employer's pharmacy reference database) only references dyspnea (shortness of breath) specifically for wellbutrin with an incidence of ≥1%. Given that my air hunger never correlated to any outwardly observable signs other than mild tachycardia (no O2 changes), it's safe to conclude the sensation was neuropsychiatric in origin / somatic anxiety. Both entries do also list the following incidences of adverse reactions relevant to anxiety:
Wellbutrin (bupropion alone):
Auvelity (bupropion + Dextromethorphan):
Now, Auvelity also has a much shorter list overall likely due to it being a much newer and therefore less studied medication. That said I'm seeing a much higher incidence of things like drowsiness with Auvelity (7%) vs Wellbutrin (2-3%). That suggests that the dextromethorphan IS offsetting the stimulating effect of the Bupropion. The question is whether it'll hit me as a smooth buzz or a delirious haze. Given that the bupropion did improve my attention even with the air hunger I would hope it would be the former but I think I'd want to take a few weeks of vacation to see. Maybe next year.
OH also: did you take wellbutrin or zyban? Brand name zyban was much more expensive than wellbutrin due to "officially" being approved for nicotine cessation. Although if it was super recent probably not because everybody just started giving their smoker patients wellbutrin off-label, which is one of a few ways doctors can just flip big pharma the bird, lol.
I was too tired when I wrote that. Vortiexone is my nothing burger. Wellbutrin has no noticable effect for me on it's own and ramps up my anxiety if I'm on other stimulants.
I haven't looked at the clinical depression treatment doses of the cold meds turned brain meds yet, but maybe? It's already a psych drug anyway that targets that reflex.
I make a point of not looking up drugs I'm trying, I take notes instead and compare later with my psyche. Right now it's a mix of Adderall, duloxetine and abilify, which work pretty well for me as a triad but none of them do much for me individually, even 20mg of adderall is like a couple coffees.
Brains are fucking weird.
You know those hipster Speakeasy's with some prodigal bartender who mixes your favorite drink? I imagine there's one of those somewhere with a mustachio'd psychopharmacologist in a rustic leather apron, who takes one look at you before he starts tossing ingredients into a mortar, with flourishes and puns. He's got a vintage copper pill press that spins on a motor, flinging tablets he catches in a green glass bottle, pops the cork stopper and hands you your ~perfect drug~