Given the direction that the Nix project is going, I suspect that many of you Nix users reading along here are currently considering alternatives, and among them Guix.
Personally I've only been using Nix for a few weeks, so my investment is not that big, but how about you? For a technical comparison, you could start with these two articles. If you're on IRC, I'd also suggest to join #guix just in case or look at the other communication options they endorse on their website.
What gives me the most thoughts is the availability of recent-ish software on Guix; but given Guix's FSF-level copyleft culture there's at least the certainty that whatever efforts I might put in to build and package things myself would have the lowest-possible likelihood of suffering corporate/fashtech capture. And we may be picking up momentum to collectively alleviate those problems.
Perfect timing haha! They might really be capitalizing on leftist/anti-fascist people moving away from NixOS. Regardless, I welcome the move.
There's a monthly Nix meetup in my area, "Nix your bugs". Never been there. I'm currently contemplating showing up there with my NixOS laptop and nix all the bugs (well, replacing them with others) by installing Guix. Given the recent developments, I don't even think most of the people who are there will consider that a dick move.
I'll definitely try to move the people I know who are interested in/users of NixOS over to Guix. Admittedly, there aren't many to begin with haha.