this post was submitted on 29 Sep 2025
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I've recently heard the phrase "anything that can be taken sublingual can be taken rectally".

Is this true and can it be applied to estrogen tablets without a shell/coating? Seems like it would bet the swallowing effect from saliva.

And a follow up question, does it need to be jammed in all the way or just past the sphincter muscle?

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[–] princessnorah@lemmy.blahaj.zone 6 points 2 days ago (1 children)

You may overdose...

It is very, very, very difficult to overdose on oestrodiol. Some quick research showed that the LD50 is >2000mg/kg. For reference, most oral oestradiol tablets are 2mg. 50kg is apparently the average weight in most places, so OP would need to shove 50,000 oestrogen tablets up her butt to have just a 50% chance of overdosing. As for the rest, plenty of people boof their progesterone pills just fine. Please try and be less alarmist.

[–] irotsoma@piefed.blahaj.zone 4 points 2 days ago (1 children)

Overdose doesn't mean die, it means getting a larger dose in your blood than the labeled dosage. Over a long period of time dosing too high, there may be side effects. Sorry if I used medical terminology, but I work in healthcare so it's common terminology there. I sometimes forget that the media has warped the meaning of some of these terms.

[–] princessnorah@lemmy.blahaj.zone 1 points 1 day ago* (last edited 1 day ago) (1 children)

Even in medical parlance, it doesn't just mean a larger than labeled dosage though. It means a large enough dose to cause adverse effects, or at the very least a quantity that is much greater than recommended. You are still being alarmist, and the fact you work in healthcare explains a lot honestly.

A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended. Typically the term is applied for cases when a risk to health is a potential result. An overdose may result in a toxic state or death.

Source.

[–] irotsoma@piefed.blahaj.zone 2 points 1 day ago* (last edited 1 day ago)

Again, adverse effects doesn't mean death, the fact that the description you posed has that last sentence is the alarmist thing and only applies to certain drugs, of course.

The difference in absorption rates between oral and rectal administration can be as much as double or triple or more in some cases. For example I remember reading a study from the 70s or 80s on methylprednisolone. The absorption rate orally was about 90%, but rectally was only around 35% likely due to bacteria in the rectum decomposing the drug before it could make it into the blood.

So, over the long term the difference in dose could have a significant impact on health. Getting 3 times more or less of any drug, even something relatively safe, will likely mean "adverse effects". With estradiol this could mean greatly increased side effects for overdose like nipple soreness or mood swings, or greatly decreased effect for underdose meaning testosterone takes over again and hair loss and body hair growth restart. These are "adverse effects", but are not likely to be deadly, but still considered overdose/underdose.