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New mRNA pill bypasses injections for gut-targeted therapy (phys.org)

submitted 5 days ago by Domino@quokk.au to c/science@mander.xyz

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[–] HubertManne@piefed.social 12 points 5 days ago (3 children)

RNACap uses pH-sensitive coatings and pressure-triggered release membranes to remain intact in the stomach. Contents are released in the intestine in response to neutral pH and peristalsis.

Nanoparticles were formulated using G0-C14, PLGA, and PEG-lipid components for mucus penetration and endosomal escape. A 5% DMPE-PEG formulation showed optimal transfection in vitro.

oh man. as a needlephobe. please. please. please.

[–] pressedhams@lemmy.blahaj.zone 8 points 5 days ago

I just saw a similar article about using this delivery method for insulin. I’m just some plebeian but it’s all very interesting!

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