Science

Van der Waals is the attraction aspect of LDF, while steric repulsion is the flipside and still a part of LDF interactions. But based on the possible substrates LDF interaction with CYP450, the active site + mechanism of action will adjust to work with what's around. Not just an allosteric aspect where a select few molecules can fit in the active site. Or at least that's my understanding of the study's findings.

Edit: The 4D aspect is referencing the LDF impact on the enzymes shape and function. LDF impacts all biochem reactions, dipole and hydrophobic forces are a bigger aspect to substrate binding though. But this breaks the mold of what we thought we knew about enzymes and opens the door for a more indepth understanding of biochemical reactions.