Longevity

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Amphiregulin Secreted by Regulatory T Cells Promotes Thymus Regeneration (www.fightaging.org)

submitted 6 months ago by RobotToaster@mander.xyz to c/longevity@mander.xyz

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[–] threelonmusketeers@sh.itjust.works 2 points 6 months ago

Thus one needs a therapy that the rest of the body can tolerate or ignore, and so far the only viable means with evidence for modest thymic regrowth are (a) calorie restriction and (b) long-term growth hormone treatment combined with other drugs to blunt the side-effects of growth hormone

Always seems to come back to calorie restriction, doesn't it? It's rough, but it works.

The cytokine amphiregulin (Areg) is specially implicated in the regenerative function of Treg cells at epithelial surfaces. In the thymus, a population of recirculating Treg cells that migrates between the periphery and the thymus coexists with newly generated Treg cells during negative selection. Here, we examined the role of Treg cells in the regeneration of the thymus after injury. We identified a unique population of Rag2GFP-CD4+Foxp3+ Treg cells that accumulate in the thymus after acute injury. Depletion and adoptive transfer of this cell population impaired and promoted, respectively, thymic repair in mice.

Hopefully these mouse studies will transfer to humans :)