this post was submitted on 23 Oct 2024
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Is it possible for somebody to achieve testosterone suppression through sublingual Estradiol tablets? I know that in theory you should be able to just take several tablets a day but I was wondering if anybody else had chosen this route?

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[–] dandelion@lemmy.blahaj.zone 10 points 9 months ago* (last edited 9 months ago) (11 children)

Sublingual results in some still being swallowed, so one concern is about putting really high doses on the liver. There is also just the logistical difficulty of dosing frequently enough to keep your levels high enough, there is less margin for error.

Why not injections for monotherapy?

[–] femtech@midwest.social 5 points 9 months ago* (last edited 9 months ago) (8 children)

What about patches? That should spread it out.

[–] dandelion@lemmy.blahaj.zone 4 points 9 months ago* (last edited 9 months ago) (7 children)

What I've heard about patches is that it can be difficult to get your estrogen high enough with them (for monotherapy at least). I've also heard other problems like rashes, the patches falling off too early (and being expensive to replace), and needing too many to make monotherapy reasonable.

Again, why not injections?

[–] femtech@midwest.social 2 points 9 months ago (1 children)

All at once, I don't want to stab myself, easier to put one on twice a week so I don't forget when lazy/tired. ESTRADIOL 0.1 MG PATCH (2/WK) is what I have.

[–] dandelion@lemmy.blahaj.zone 2 points 9 months ago* (last edited 9 months ago) (1 children)

One 0.1 mg patch isn't enough for monotherapy, but you could try multiple patches for monotherapy. What are you estradiol blood levels like with that dose?

I don't like stabbing myself either, but the benefits of injections outweigh those concerns (and I have done a lot to mitigate my needle phobia).

[–] femtech@midwest.social 2 points 9 months ago (1 children)

Well my hormones were off before I started and I'm post op now. My T before starting was 375 and my Estrogen total was 250. Now my T is 4 and my ESTRADIOL (E2) is 40

[–] dandelion@lemmy.blahaj.zone 2 points 9 months ago

oh interesting, yeah - I am pre-op, so I am relying on monotherapy to suppress my T.

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