Nature

Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08922-2

Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set to understand the most fundamental processes underlying human genetic variation.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08875-6

Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing pain, heat hypersensitivity and tactile allodynia during inflammation.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08927-x

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08913-3

Levantine Phoenicians made little genetic contribution to Punic settlements in the central and western Mediterranean between the sixth and second centuries bce; instead, the Punic people derived most of their ancestry from a genetic profile similar to that of Sicily and the Aegean, with notable contributions from North Africa as well.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08781-x

Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure and demonstrate the human gutʼs capacity to promote resistance evolution.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08918-y

The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid-transport proteins.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01161-5

Bacterial resistance to antibiotics is a growing health threat, but its evolution outside laboratory settings is poorly understood. Bacteria living in the human gut are now found to evolve persistent resistance after brief exposure to antibiotics, and factors that promote this evolution have been identified, highlighting the gut as a potential hotspot for this process.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01164-2

The genetic bases of the seven pairs of contrasting traits in the garden pea that were described by the ‘father of genetics’, Gregor Mendel, have long puzzled scientists. The discovery of the genetic variants underlying these traits sheds light on the ‘inherited factors’ that Mendel proposed and how they shape biological differences.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01133-9

Immune cells boost stress-linked fear responses by communicating with brain cells. One way that psychedelics lessen such fear is by modulating this interaction.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01152-6

Emerging companies and an evolving market are changing the dynamics of cancer trials.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01190-0

Neuroscientist Jessica Cantlon is urging scientists to use the power of local newspapers in the fight against US research-funding cuts.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01131-x

An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01155-3

These scientists are coming at cancer from all angles.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01238-1

A three-part Nature Podcast series explores the importance of scientific naming conventions — and talks to researchers looking at how to make them more inclusive.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01167-z

The high-resolution structure of a bridge-like lipid-transfer protein that moves lipids between cellular compartments shows how these ‘lipid superhighways’ operate.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01150-8

Vaccine scepticism could undermine important progress in cancer research.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01087-y

Scans of 18 ancient papyri that were buried by the eruption of Mount Vesuvius look ‘very promising’, and there are plans to digitally unroll many more.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01085-0

A protein pair that influences how damage to cardiac muscle fluctuates with circadian rhythm could be the key to optimizing heart-attack recovery.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01233-6

With the world set to blow past its temperature targets, efforts are growing to remove greenhouse gases from the atmosphere.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01153-5

Cancer blood tests and AI-powered scans look promising for quicker and more accurate detection of disease.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01132-w

Neurons involved in forming memories of a cold environment communicate with the part of the brain that regulates metabolic responses to cold stress.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01156-2

A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01269-8

Researchers pinpoint the genes responsible for the final three pea traits studied by the famed citizen scientist.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01243-4

Seeing red.

From Nature via this RSS feed

Nature, Published online: 23 April 2025; doi:10.1038/d41586-025-01151-7

Fresh optimism surrounds initiatives to treat existing disease.

From Nature via this RSS feed